Throughout her 25 years on television, Oprah filled us with beautiful sermons for the soul.

Whether speaking on friendships, love or money, you could always count on the queen of media to inspire and motivate. And now, as she readies for her next job teaching “Life 101” to students at her South African school, we take a look back at some of the wisdom she will surely be passing on to them.

Here are 20 of Oprah’s most inspirational quotes.